What is the role of reelin in the brain? According to Figure 5, how does the expression of reelin in the prefrontal cortex of schizophrenic patients differ from reelin expression in non-psychotic subjects
Study the promoter methylation data shown in Figure 6. How does the overall level of methylation of the reelin promoter in schizophrenic brains compare to the methylation of the reelin promoter in non-psychotic control brains? What would be the most probable effect of this methylation pattern on the expression of reelin in patients with schizophrenia?
What is the enzyme responsible for methylating DNA? How does a drug like doxorubicin affect DNA methylation?
In reference to Figure 7, what is the effect of doxorubicin treatment on the expression of reelin in NT-2 cells? How does increasing amounts of doxorubicin affect reelin expression in these cells?
Based on these data, might a drug like doxorubicin be a potential treatment for schizophrenia? Why or why not? What additional experiments should be performed before a drug like doxorubicin goes into clinical trials?
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